A therapeutical outlook in "infectious" bronchial asthma
Olinescu, A.; Leveneţ, I.
Roumanian Archives of Microbiology and Immunology 59(1-2): 31-41
2000
ISSN/ISBN: 1222-3891 PMID: 11845473 Document Number: 524348
Chronic bronchial asthma seems to be generated by abnormal functions of PMNs and eosinophils stimulated by local bacterial flora. Once stimulated, they release uncontrolled excessive amounts of ROI and various soluble mediators. These are the expression of disorders in the synthesis of SOD, catalase and other enzymes by PMNs and an excessive production of the so-called anti-inflammatory Th2 type cytokines, mainly IL-4 and IL-5 to the detriment of IFN gamma and other Th1 type cytokines. Treatment consisting of autovaccines obtained from local flora associated with immunomodulators instead of antibiotics or glucocorticoids proved to be beneficial for patients.