Effects of adrenergic receptor blockers on adrenaline and nicotine-induced hyperglycaemia in the rat
Oyebola, D.D.; Alada, A.R.
African Journal of Medicine and Medical Sciences 22(4): 13-18
1993
ISSN/ISBN: 0309-3913 PMID: 7839924 Document Number: 5238
Studies in fasted, anaesthetized rats have shown that adrenaline and nicotine-induced hyperglycaemia is mediated via activation of beta-adrenoceptors. The hyperglycaemic response to nicotine is different from that of adrenaline in that, unlike adrenaline hyperglycaemia, nicotine hyperglycaemia is characterized by a long latent period, delayed attainment of peak of response and sustained hyperglycaemia throughout the 120 minutes post-injection observation. Comparison with previous studies in dogs showed that different receptors are involved in nicotine hyperglycaemia in fasted dogs and fasted rats.
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