Topical antimicrobial activity of 6-methoxy-1-phenazinol 5,10-dioxide, cupric complex
Maestrone, G.; Darker, R.; Hemrick, F.; Mitrovic, M.
American Journal of Veterinary Research 33(1): 185-193
1972
ISSN/ISBN: 0002-9645 PMID: 4621697 Document Number: 52212
Copper myxin is a dark green, microcrystalline powder of high melting point, which is insoluble in conventional solvents. It was used as a suspension in distilled water, or formulated as a water-washable cream. The myxin was compared with penicillin, streptomycin, oxytetracycline, nitrofurazone and sulfadimethoxine for in vitro antibacterial activity (in the presence of milk or high concentrations of animal protein), and with nystatin, amphotericin and tolnaftate for anti-yeast and antifungal activity. It compared favourably with the compounds most effective in each field, and was less affected by protein than most. Static and cidal concentrations were generally the same. Copper myxin also compared favourably with the above compounds during in vivo tests on mice (s/c injection of seeded and treated milk). Both 0.1 and 0.5% creams were more effective than oxytetracycline, polymyxin B or nitrofurazone preparations in treatment of rabbits with induced Staph. aureus of aeruginosa lesions, and cidal activity persisted four days after treatment. The cream was more effective than nystatin in treating induced C. albicans lesions in rabbits and than tolnaftate or undecylenic acid in treating T. mentagrophytes in g.pig. The two last products had better fungicidal activity, but could not control parallel infection with bacteria and yeasts. Copper myxin was non-irritant to lab. animals.