Top Abstract Purchase Preview Related
Home
>
Node
>
Subnode

Effect of Silubin-retard (1-butyl-biguanide hydrochloride) on the course of influenza-virus infection in mice

Denys, A.; Bocian, J.

Polski Tygodnik Lekarski 25(9): 332-334

1970

ISSN/ISBN: 0032-3756
PMID: 5447272
Document Number: 5212
The authors investigated the effect of subcutaneous injection of Silubin-Retard produced by Chemie Grünenthal, West Germany (1-butyl-biguanide hydrochloride) on the course of experimental infection with APR-8 influenza virus of mice. The dose of the virus used for infection was 1 LD50. The preparation was given 24 hours prior to infection in a dose of 20 mg/kg and it was given during 4 days. A good protective effect of the agent was observed. The mortality of mice fell. The authors stress the necessity of watching for the potentially antiviral activity of drugs derivatives of biguanide having various pharmacological properties.

Document emailed within 1 workday
Secure & encrypted payments

Effect of Silubin-retard (1-butyl-biguanide hydrochloride) on the course of influenza-virus infection in mice

Tomas, E.; Samuel, I. 1975: Effect of ceruloplasmin on AoPR8 influenza virus infection in embryonate eggs and mice Virologie 26(1): 57-61
Reinacher, M.; Bonin, J.; Narayan, O.; Scholtissek, C. 1983: Pathogenesis of neurovirulent influenza a virus infection in mice. Route of entry of virus into brain determines infection of different populations of cells Laboratory Investigation; a Journal of Technical Methods and Pathology 49(6): 686-692
Denys, A. 1970: Studies of the effect of guanidine hydrochloride on influenza viruses. I. Inactivation of influenza virus and some other viruses Medycyna Doswiadczalna i Mikrobiologia 22(3): 243-248
Kobets, N.V.; Chernyakhovskaya, I.Y.; Fontalin, L.N. 1995: Peculiarities of virus-specific immune response in mice with congenitally acquired influenza infection Folia Biologica 41(6): 295-303
Maeda, H. 1997: Deleterious pathogenic mechanism involving host response in influenza virus infection in mice Nihon Rinsho. Japanese Journal of Clinical Medicine 55(10): 2676-2681
Kimura, Y. 2000: Pathophysiological events in the central nervous system of mice during neurovirulent influenza A virus infection Nihon Rinsho. Japanese Journal of Clinical Medicine 58(11): 2211-2216
Zuev, V.A.; Peters, V.V.; Azadova, N.B. 1971: Latent infection of cell cultures, insensitive to the cytopathic effect of a virus. Isolation of influenza virus from latently infected cells Voprosy Virusologii 16(6): 713-718
Stelmakh, T.A.; Medvedeva, M.N.; Golubev, D.B. 1982: Analysis of specific interactions influenza virus and cells of different sensitivity. Note 2. Characteristics of influenza virus-host cell interaction in persistent infection Virologie 33(1): 47-51
Del Gobbo, V.; Caliò-Villani, N.; Garaci, E.; Caliò, R. 1985: PR8 influenza virus infection impairs serum thymic activity levels and thymus-derived immune functions in mice Bollettino dell'Istituto Sieroterapico Milanese 64(3): 207-215
Prahoveanu, E.; Eşanu, V.; Anton, G.; Frunzulică, S. 1986: Prophylactic effect of a Beta vulgaris extract on experimental influenza infection in mice Virologie 37(2): 121-123
Zarubaev, V.V.; Garshinina, A.V.; Kalinina, N.A.; Shtro, A.A.; Beliaevskaia, S.V.; Nebol'sin, V.E.; Kiselev, O.I. 2010: Protective activity of Ingavirin in experimental lethal influenza due to pandemic influenza virus a (H1N1)v in albino mice Antibiotiki i Khimioterapiia 55(5-6): 24-31
Kantorovich-Prokudina, E.N.; Kaverin, N.V.; Semenova, N.P.; Miasnikova, I.A.; Berezina, O.N. 1978: Preventive effect of UV-inactivated defective interfering influenza virus in experimental infection Voprosy Virusologii 1978(6): 673-677
Demina, O.K.; Sergeev, A.A.; Agafonov, A.P.; Shikov, A.N.; Sementsova, A.O.; Sergeev, A.A.; Sergeev, A.N.; Drozdov, I.G. 2009: Investigation of therapeutic and protective effect of Reaferon-ES Lipint on mice infected with avian influenza virus (subtype H5N1) Antibiotiki i Khimioterapiia 54(9-10): 27-29
Szulc, B.; Szalaty, H. 1980: Effect on influenza virus infection on the production of interferon by alveolar and peritoneal cells in vitro Archivum Immunologiae et Therapiae Experimentalis 28(1): 93-97
Smirnov, V.S.; Garshinina, A.V.; Shtro, A.A.; Anikin, V.B.; Galochkina, A.V.; Beliavskaia, S.V.; Zarubaev, V.V. 2014: Anti-viral activity of a complex of the glycyrrhizic acid-alpha-glutamyltryptophan against the experimental lethal influenza infection in white mice caused by the oseltamivir-resistant strain of the virus Voprosy Virusologii 59(5): 31-38
Epstein, S.L.; Misplon, J.A.; Lawson, C.M.; Subbarao, E.K.; Connors, M.; Murphy, B.R. 1993: Beta 2-microglobulin-deficient mice can be protected against influenza a infection by vaccination with vaccinia-influenza recombinants expressing hemagglutinin and neuraminidase Journal of Immunology 150(12): 5484-5493
Nefedova, N.B.; Gordeeva, M.S.; Zuev, V.A. 1990: Effect of maternal virus-specific T-lymphocytes on pregnancy and fetal pathogenesis in experimental congenital influenza infection Voprosy Virusologii 35(6): 456-458
Semkow, R.; Zgorzelska, K.; Brydak, L. 1971: Studies on the adaptation of freshly isolated strains of influenza virus. II. Endogenous respiration of the organs in virus-infected mice Medycyna Doswiadczalna i Mikrobiologia 23(2): 141-146
Stoeva, E.; Tantcheva, L.; Mileva, M.; Savov, V.; Galabov, A.S.; Braykova, A. 2001: Preventive effect of vitamin E on the processes of free radical lipid peroxidation and monooxygenase enzyme activity in experimental influenza virus infection Advances in Experimental Medicine and Biology 500: 257-260
Bocharov, E.F.; Shalaurova, O.V. 1979: Effect of coxsackie virus infection on the immune response of mice to sheep erythrocytes Acta Virologica 23(4): 351