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Screening and search for novel inhibitors of DD-peptidase 64-575

Rozbicka, B.; Kurzatkowski, W.

Acta Poloniae Pharmaceutica 57 Suppl: 8-10

2000

ISSN/ISBN: 0001-6837
PMID: 11293273
Document Number: 520702
The aim of the work was search for inhibitors of PBPs (penicillin binding proteins, DD-carboxypeptidase/transpeptidase, DD-peptidase). Between 141 tested Streptomyces strains, 25% showed activity of inhibitors production. The inhibitors were produced by selected Streptomyces strains (NIH Culture Collection). The culture supernatants of Streptomyces rimosus B PZH (inhibitor B) and Streptomyces rimosus NRRL 2234 (inhibitor 2234) exhibited the highest inhibition activity. Both inhibitors were purified by the use of: anion exchange chromatography and reversed phase chromatography (HPLC). Inhibitor B is a gamma-lactam compound and inhibitor 2234 is a beta-lactam.

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