Hepatic arterial injection therapy (HAI) for metastatic liver tumor from gastric cancer
Nagahama, T.; Maruyama, M.; Toukairin, Y.; Baba, H.; Yoshida, T.; Kure, N.; Ebuchi, M.; Yamada, F.; Ikeda, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 27(12): 1920-1923
2000
ISSN/ISBN: 0385-0684 PMID: 11086446 Document Number: 517787
The results and problems of hepatic artery infusion therapy (HAI) for gastric carcinoma with synchronous liver metastasis were evaluated. The response rate of HAI with CDDP and 5-FU for metastatic liver tumor was 55% (1 CR + 5 PR/11). The median survival time for responders was 16.5 months, which was statistically longer than that of non-responders at only 5.5 months. Histologically, most responder cases were with AFP producing tumors and NSE positive tumors without distant lymph node involvement. Non-responder cases developed marked distant lymph node involvement besides the liver metastasis. Most of responder patients died of lymph node recurrence or distant metastasis other than liver tumor. It may be concluded that additional therapy to HAI is needed to improve the prognosis of gastric cancer patients with multiple liver metastases.