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A recurrent case of esophageal cancer in which metastatic skin tumor disappeared after local injection of activated lymphocytes with tumor-pulsed dendritic cells

Nagao, N.; Katoh, M.; Kumazawa, I.; Tomita, H.; Sugiyama, Y.; Kunieda, K.; Miya, K.; Saji, S.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 26(12): 1937-1939

1999

ISSN/ISBN: 0385-0684
PMID: 10560430
Document Number: 502246
We examined the effect of activated lymphocytes stimulated with tumor-pulsed dendritic cells (DC-K), and found that such stimulation enhanced the cytotoxity of the activated lymphocytes. Furthermore, in applying DC-K to a recurrent case of esophageal cancer, the skin tumors disappeared after local injection of DC-K. The only adverse effect of this treatment was pyrexia. Although no general effect was observed, the local effect was satisfactory. This suggests that DC-K might be useful for local treatment or postoperative adjuvant therapy.

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