Diflucortolone valerate (Nerisona) : a comparative vasoconstriction test in artificially induced hyperemia of the skin

Reckers, R.; Wendt, H.

Clinical Therapeutics 3(3): 190-193

1980


ISSN/ISBN: 0149-2918
PMID: 7459929
Document Number: 5172
In 20 healthy volunteers of both sexes the vasoconstrictive activity of diflucortolone valerate in two of its commercially available formulations (water-in-oil emulsion and pure fat base) was compared with that of four other substances: fluocinonide; betamethasone-17,21-dipropionate; hydrocortisone-17-butyrate; and clobetasol-17-propionate in corresponding galenical formulations. The visual assessment of vasoconstrictive activity after 10 hours revealed a statistically significant superiority of diflucortolone valerate in its fat base over the corresponding galenical formulations of fluocinonide, clobetasol-17-propionate, and hydrocortisone-17-butyrate. Diflucortolone valerate in a water-in-oil emulsion was statistically better after eight hours than the cream formulations of fluocinonide; clobetasol-17-propionate, and betamethasone-17,21-dipropionate.

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Diflucortolone valerate (Nerisona): a comparative vasoconstriction test in artificially induced hyperemia of the skin