A comparative multicentre trial of halometasone/triclosan cream and diflucortolone valerate/chlorquinaldol cream in the treatment of acute dermatomycoses
Maeder, E.; Schindléry, C.; Macarol, V.; Schoenenberger, P.M.
Journal of International Medical Research 11(Suppl): 48-52
1983
ISSN/ISBN: 0300-0605 PMID: 6339293 Document Number: 213109
The efficacy and tolerability of a cream containing 0.05% halometasone and 1% triclosan was compared with those of Nerisona C cream, containing 0.1% diflucortolone valerate and 1% chlorquinaldol, in 183 patients with acute dermatomycoses. Halometasone/triclosan cream and the comparative cream showed closely similar results with respect to good to very good therapeutic effects (60 vs. 57%). Halometasone/triclosan cream was superior to the comparative preparation with regard to very good (cured) results (53 vs. 46%), an early cure in < 30 days (41 vs. 34%) and onset of action within 3 days of starting the treatment (32 vs. 18%). Mycological findings were positive on direct microscopy in 36 and 43% and in culture in 19 and 17% of the patients following treatment with halometasone/triclosan cream and the comparative cream preparation, respectively. Adverse effects were reported in 7 of 108 patients treated with halometasone/triclosan cream and in 5 of 107 patients treated with the comparative preparation.