Heterochromatin and single-strand DNA breaks (a hypothesis)
Gruzdev, A.D.
Genetika 35(7): 869-872
1999
ISSN/ISBN: 0016-6758 PMID: 10519065 Document Number: 509090
A hypothesis is put forward which explains the known heterochromatin properties: dense DNA packing, transcriptional inactivity, a tendency for aggregation (adhesiveness) and ectopic contacts. The basic assumption of the hypothesis is that the DNA molecules in heterochromatin are topologically open and contain single-strand breaks in the regions with the same or similar base sequence.
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