A cell and genotoxic stress: a reaction to double strand breaks of DNA
Rezácová, M.; Vávrová, J.; Cerman, J.
Casopis Lekaru Ceskych 144(Suppl 3): 13-17
2005
ISSN/ISBN: 0008-7335 PMID: 16335257 Document Number: 594304
Double strand breaks (DSB) of DNA represent a major impact on the genome integrity. Cells have developed complex set of reactions for prevention of genotoxic damage and cellular dysfunction. The quickly reacting proteins of human cells include proteinkinases from the family of phophatidylinositol-3-kinase related proteinkinases: ataxia-teleangiectasia mutated (ATM), ataxia-teleangiectasia and Rad3-related (ATR) and catalytic subunit of DNA-dependant proteinkinase (DNA-PKcs). Activated ATM phosphorylates other targets, including proteins p53, Mdm2, Chk1, Chk2, Brca1, Nbs1 and cAb1. This article discusses the molecular response to DSB in detail.