Changes in human chromosomes caused by some drugs
Vrba, M.
Ceskoslovenska Oftalmologie 27(3): 134-139
1971
ISSN/ISBN: 0009-059X PMID: 4996775 Document Number: 5068
In human heamocultures and line of HeLa cells chromosomal changes have been Mdruced by cyclophosphamide, atropine, scopolamine, homatropine, ampliciline and EDTA. The strongest inductor was activated cyclophosphamide, which induced a chromatide type of chromosomal changes. The other medicaments caused mostly a non specific aggregation of the chromosomes and their use bears no danger of genetic transformation of somatic cells.
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