Central action of cyclic: 3',5'-thymidine, 3',5'-uridine and 3',5'-citidine monophosphates in rat

Brus, R.; Herman, Z.S.; Juraszczyk, Z.; Krzemiński, T.; Trzeciak, H.; Kurcok, A.

Acta Medica Polona 25(1-4): 1-9

1984


ISSN/ISBN: 0001-608X
PMID: 6100154
Document Number: 5067
Behaviour, temperature, reactivity on thermic pain stimulus and vegetative phenomena (blood pressure, heart and respiration rates) were studied in rats treated with synthetic cyclic nucleotides (cyclic 3',5'-thymidine monphosphate, cTMP, cyclic 3',5'-uridine mono phosphate, cUMP, cyclic 3'5'-citidine monophosphate, cCMP). These substances were administered into lateral cerebral ventricle in the dose of 31 and 310 nmol. It has been demonstrated that all studied nucleotides inhibited the motoric activity, diminished the exploratory activity and evoked hypothermia. cUMP was found to act strongest and longest, cCMP-shortest. The reactivity on the termal pain stimulus markedly fell after the administration of cTMP. but cUMP and cTMP acted weaker. The strongest hypotensive effect was exerted by cCMP, the weakest - by cTMP. The effect of investigated nucleotides on the heart and respiration rates was negligible. These experiments make evident that intraventricularly administered cTMP, cUMP and cCMP act biologically on the central nervous system changing the behaviour of rats and causing vegetative disturbances.

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Central action of cyclic: 3',5'-thymidine, 3',5'-uridine and 3',5'-citidine monophosphates in rat