Frequency of sex chromosome nondisjunction as affected by microtubule destabilization and heat shock in various lines of Drosophila melanogaster
Shvartsman, P.I.; Isaenko, O.A.
Genetika 35(7): 891-897
1999
ISSN/ISBN: 0016-6758 PMID: 10519067 Document Number: 502150
Vinblastine (Vb), a drug belonging to a group of mitotic poisons, was shown to induce sexual chromosome nondisjunction and loss (SCNL) in oogenesis of different strains of Drosophila melanogaster. Heat shock (37 degrees C, 45 min) decreases the frequency of these events. The highest level of nondisjunction was demonstrated in the temperature-sensitive strain both after heat shock and Vb treatment. No increase of SCNL frequency in oocytes of females treated with griseofulvin (Gf) and Colchicine (Cl), analogues of Vb.