The histopathologic picture of experimental poisoning with ethylmethacrylates
Nádvorník, F.; Schneiderka, P.; Roosová, M.; Vacík, J.; Labský, J.
Soudni Lekarstvi 43(2): 14-24
1998
ISSN/ISBN: 0371-1854 PMID: 9624832 Document Number: 497170
Toxic effect of hydroxyethylmethacrylate, acetoxyethylmethacrylate and diethylenglycomethacrylate were studied in rats surviving as long as 1 to 20 days after intramuscular administration. Conspicuous lesion were found only in calf muscles at the site of application. Muscle fibre necroses with inflammatory reaction occurred repeatedly in animals surviving 1-2 days. Newly formed connective tissue replacing impaired muscle fibres was found in rats surviving 5 days. Intoxication related other lesion in rat organs were not identified.