Etiopathogenetic and histopathologic aspects of acute necrotico-hemorrhagic pancreatitis in experimental animals
Borghese, M.; Rengo, M.; Schiffino, L.; Galati, G.; Scarpini, M.; Caramanico, L.; Leone, G.; De Toma, G.; Bruni, R.
Il Giornale di Chirurgia 10(5): 280-283
1989
ISSN/ISBN: 0391-9005 PMID: 2518569 Document Number: 347465
In this study, the Authors have provoked experimentally acute pancreatitis in the rat by different methods, in order to find out morphological modifications of the pancreas in the initial stage of the disease. In case of biliary and pancreatic duct obstruction with pure pancreatic reflux, both oedema and inflammatory infiltrations were evident, whereas, in the presence of biliary reflux too, more serious histological features were detected. In conclusion, the first sign of alteration in acute pancreatitis could be represented by the association of intraductal hypertension and pure pancreatic reflux.