Mathematical modeling of energy coupling in mitochondria in frames of proton-chemical hypothesis
Lemeshko, V.V.; Anishkin, A.G.
Biofizika 43(2): 308-314
1998
ISSN/ISBN: 0006-3029 PMID: 9591105 Document Number: 496916
The dependence of ATP-synthesis and mitochondria respiration rates on membrane potential was analyzed in frames of proton-chemical hypothesis of oxidative phosphorylation. The mathematical and electrical models of the unit of energy coupling are proposed. Computer analysis of the mathematical model allowed to obtain the theoretical dependence of the rates of ATP synthesis and of the respiration on the membrane potential. Both of all are in good qualitative agreement with experimental data, contradicting chemiosmotic hypothesis.