Calcium transport and energy coupling in diabetic rat liver mitochondria
Grinblat, L.; Bedetti, C.D.; Stoppani, A.O.
Biochemistry International 17(2): 329-335
1988
ISSN/ISBN: 0158-5231 PMID: 3190727 Document Number: 310418
Liver mitochondria from chronic diabetic rats took up Ca ions at a significantly slower rate than their normal counterparts. The same mitochondria, inhibited with ruthenium red, released Ca ions at a faster rate than normal mitochondria. In good agreement with the decrease of Ca ions uptake, measurement of the inner membrane potential by the saranine method yielded a significantly lower values with diabetic than with normal mitochondria. Respiratory control and P/O ratios were also decreased in diabetic mitochondria.