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Development of a test system for detection of anti-endotoxic immunity in young children, healthy donors and some groups of therapeutic patients

Uvitskiĭ, A.I.; Pagnueva, L.I.; Popova, E.D.; Khasanova, R.B.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2: 18-21

1998

ISSN/ISBN: 0372-9311
PMID: 9662790
Document Number: 496912
The content of antibodies to soluble lipid A detritus was studied with the use of the enzyme immunoassay techniques. Some regularities of anti-endotoxic immunity were established: the elevated level of anti-lipid A antibodies in chronic bronchial tree diseases of bacterial etiology. On the other hand, cases of severe purulent septic infections in young children were found to be accompanied by a considerable decrease in the titer of anti-endotoxic antibodies. The approaches to the therapy of diseases caused by Gram-negative bacteria by means of specific immunoglobulins are discussed.

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