3- (p-Chlorophenyl) -4-aminobutanoic acid--resolution into enantiomers and pharmacological activity
Witczuk, B.; Khaunina, R.A.; Kupryszewski, G.
Polish Journal of Pharmacology and Pharmacy 32(2): 187-196
1980
ISSN/ISBN: 0301-0244 PMID: 7454623 Document Number: 4902
Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to be 4.2-9.2-fold as effective as the S(-) one and 1.4-1.9-fold as effective as the racemate.
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