Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers
Blaschke, G.; Kraft, H.P.; Fickentscher, K.; Köhler, F.
Arzneimittel-Forschung 29(10): 1640-1642
1979
ISSN/ISBN: 0004-4172 PMID: 583234 Document Number: 3872
Racemic thalidomide is chromatographically separated on optically active polyamide giving both enantiomers. After i.p. administration only the S-(-)-enantiomer is teratogenic on SWS mice and Natal rats.
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