Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers

Blaschke, G.; Kraft, H.P.; Fickentscher, K.; Köhler, F.

Arzneimittel-Forschung 29(10): 1640-1642

1979


ISSN/ISBN: 0004-4172
PMID: 583234
Document Number: 3872
Racemic thalidomide is chromatographically separated on optically active polyamide giving both enantiomers. After i.p. administration only the S-(-)-enantiomer is teratogenic on SWS mice and Natal rats.

Document emailed within 1 workday
Secure & encrypted payments

Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers