CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility
Gao, J.; Ren, C.; Zhang, Q.
Zhonghua Zhong Liu Za Zhi 20(3): 185-186
1998
ISSN/ISBN: 0253-3766 PMID: 10921002 Document Number: 489681
To evaluate the relationship between CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility among Cantonese in China. In a case-control study, PCR was used to identify CYP2D6 and GSTM1 genotypes and restriction enzyme BstNI was used to identify a specific point mutation of CYP2D6. Between lung cancer patient group and normal control group CYP2D6 genetic polymorphism did not show frequency distribution differences but that of GSTM1 did (58.7% n = 46, 35.7%, n = 70, P < 0.05) OR = 2.56(1.11-2.44). There is no association between CYP2D6 G-A mutation and lung cancer susceptibility, while individuals with GSTM1 -/- genotype are susceptible to lung cancer.