Genetic susceptibility to cancer
Stoica, O.; Sandovici, I.; Covic, M.
Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 104(2): 21-30
2000
ISSN/ISBN: 0048-7848 PMID: 12089987 Document Number: 525531
Hereditary predisposition is a common trait of many cancers. 15 to 20 percent of all cancers occur in individuals who have inherited a single gene alteration being members of families where multiple persons carry a high risk of developing cancer. Other than these so-called high penetrance genes which confer elevated risks of cancer development, there are many other genes that generate less dramatic but clinically important risks of cancer, often only if associated to specific exposures.