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Functional Bax polymorphism associated with lung cancer susceptibility

Yu, D.-k.; Guo, Y.-l.; Tan, W.; Lin, D.-x.

Zhonghua Zhong Liu Za Zhi 32(5): 324-327

2010

ISSN/ISBN: 0253-3766
PMID: 20723427
Document Number: 645337
The Bcl-2 associated X protein (Bax), belonging to the Bcl-2 family, plays a pivotal role in mitochondria-dependent apoptosis. The aims of this study are to revalidate the functional significance of Bax G(-248)A polymorphism, and investigate its association with lung cancer risk in Chinese population. The biological function of Bax G(-248)A was tested by luciferase assays, and its effects on lung cancer risk was determined by case-control analysis of 989 patients with lung cancer and 990 controls. Bax -248A allele exhibited significantly higher transcriptional activity compared with G allele. The Bax-248A allele carriers yielded a significantly decreased risk of lung cancer, compared with -248G allele carriers (OR = 0.68, 95% CI = 0.48 approximately 0.90, P = 0.01). Furthermore, a significant gene-smoking interaction between Bax G(-248)A polymorphism and smoking existed among the light smokers. Bax G(-248)A polymorphism is associated with lung cancer susceptibility in Chinese population.

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