Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the smoking--lung cancer association
Ratnasinghe, D.; Tangrea, J.A.; Stewart, C.; Bhat, N.K.; Virtamo, J.; Albanes, D.; Taylor, P.R.
Anticancer Research 21(2b): 1295-1299
2001
ISSN/ISBN: 0250-7005 PMID: 11396202 Document Number: 537790
To evaluate the association between CYP1A1 genotype and lung cancer risk and to assess the effect of CYP1A1 genotype and antioxidant supplementation on the smoking--lung cancer relationship we conducted a case-control study nested within a large cancer prevention trial cohort. Controls (n = 324) were matched to cases (n = 282) on age (+/- 5 years), intervention group and study clinic in a 1:1 ratio, using incidence density sampling. Genotype was determined by a PCR-based method and logistic regression was used to calculate relative risk estimates. Overall, we found no association between CYP1A1 genotype and lung cancer risk. CYP1A1 genotype did not modify the effect of smoking on lung cancer risk. However, in an examination of subgroups defined by randomized intervention assignment our findings suggest that alpha-tocopherol supplementation may reduce the risk of lung cancer associated with cumulative smoking exposure regardless of CYP1A1 genotype with the greatest effect seen among those with the variant CYP1A1 allele.