Experimentally induced actin depolymerization disrupts the adaptive state of a neuron
Pavlik, L.L.; Tiras, N.R.; Moshkov, D.A.
Morfologiia 114(4): 24-27
1998
ISSN/ISBN: 1026-3543 PMID: 9826813 Document Number: 487317
The state of filament actin in Mauthner neuron (MN) of gold-fish adapted to long-term natural stimulation was investigated after introduction of actin-depolymerizing cytochalasin D. Cytochalasin was demonstrated to cause almost complete disappearance of long actin bundles that were characteristic for the cytoplasm of adapted fish and were absent from MN of intact fish. Polymeric actin supporting the cytoskeleton integrity was suggested to be involved in mechanisms underlying the increase of MN resistance extreme loads.