Taxuspine D, a new taxane diterpene from Taxus cuspidata with potent inhibitory activity against Ca (2+) -induced depolymerization of microtubules
Kobayashi, J.; Hosoyama, H.; Shigemori, H.; Koiso, Y.; Iwasaki, S.
Experientia 51(6): 592-595
1995
ISSN/ISBN: 0014-4754 PMID: 7607303 Document Number: 453210
A new taxane diterpenoid, taxuspine D (1), possessing an enolacetate moiety, has been isolated from stems of the Japanese yew Taxus cuspidata Sieb. et Zucc., and the structure elucidated on the basis of spectroscopic data. Taxuspine D (1) markedly inhibited Ca(2+)-induced depolymerization of microtubules.
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