Active efflux of norfloxacin by Bacteroides fragilis
Miyamae, S.; Nikaido, H.; Tanaka, Y.; Yoshimura, F.
Antimicrobial Agents and ChemoTherapy 42(8): 2119-2121
1998
ISSN/ISBN: 0066-4804 PMID: 9687419 Document Number: 486979
Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the efflux is catalyzed by a multidrug pump with specificity similar to that of NorA/Bmr.
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