A new class-IIi antiarrhythmic preparation among the dicyclohexylamides of aminocarboxylic acids
Kaverina, N.V.; Lyskovtsev, V.V.; Sokolov, S.F.; Poppe, H.; Marx, D.; Kishchuk, E.P.; Turilova, A.I.; Likhosherstov, A.M.; Tsorin, I.B.; Chichkanov, G.G.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 11: 42-46
1998
ISSN/ISBN: 0869-6047 PMID: 9889705 Document Number: 486546
The Institute of Pharmacology, Academy of Medical Sciences, jointly with AWD (Germany) has synthesized and tested a novel class III antiarrhythmic coded AWD-160-275, a derivative of dicyclohexylamides of aminocarboxylic acids. The compound was shown to prolong cardiac repolarization, to increase atrial and ventricular refractory periods, to decrease sinus nodal automatism, and to unchange intraventricular conduction. The compound proved to be superior to the reference drugs in the rate and duration of antiarrhythmic and antifibrillatory action. In therapeutical doses it has no antiarrhythmic effect. The specific feature of the agent is that there is no relation of longer effective refractory periods to the frequency of stimulation. This property may be useful in treating tachyarrhythmias.