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Influence of new IIi class antiarrhythmic drug Niferidil (RG-2) on bioelectrical activity of rat pulmonary veins myocardium

Egorov, I.V.; Stolbova, V.I.; Kuz'min, V.S.; Rozenshtraukh, L.V.

Kardiologiia 52(2): 47-51

2012

ISSN/ISBN: 0022-9040
PMID: 22792739
Document Number: 661195
Myocardial cells in pulmonary veins are thought to play a major role in the initiation and maintenance of atrial arrhythmias, including atrial fibrillation. In experiments on rat pulmonary veins, antiarrhythmic drug niferidil (RG-2) produced increase of APD90% and functional refractory period and decrease of action potential amplitude and slope of APD restitution curve. Thus niferidil (RG-2) exerts stronger action on pulmonary veins than left atrium. This can take important part in Niferidil (RG-2) antiarrhythmic activity.

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