Ionic mechanisms of cardiotropic action of a new class IIi antiarrhythmic drug RG-2
Reznik, A.V.; Fedorov, V.V.; Kokoz, I.M.; Korystova, A.F.; Rozenshtraukh, L.V.; Golitsyn, S.P.; Ruda, M.I.; Chazov, E.I.
Kardiologiia 43(10): 76-81
2003
ISSN/ISBN: 0022-9040 PMID: 14593359 Document Number: 556112
A perforated patch-clamp analysis of the effect of a novel class III antiarrhythmic agent RG-2, on voltage-dependent currents was made in rat ventricular myocytes. In these cells, RG-2 decreased delayed rectifier outward K(+) current, I(k), in concentration dependent manner with threshold concentration 0.1 microM/l. In contrast, the drug did not have significant effects on the transient outward and inward rectifier K(+) current. RG-2 in concentration dependent manner decreased Ca(2+) current (I(Ca,L)) with threshold concentration 1 microM/l, tenfold higher than threshold concentration for I(k). We can conclude that decreasing of I(k) may explain prolongation of cardiac repolarization induced by RG-2, and contribute to its antiarrhythmic action.