Fluorescence assays for screening combinatorial libraries of drug candidates
Finney, N.S.
Current Opinion in Drug Discovery and Development 1(1): 98-105
1998
ISSN/ISBN: 1367-6733 PMID: 19649796 Document Number: 486107
The following subjects will be addressed sequentially: recent advances in the application of the green fluorescent protein (GFP) to monitoring biological processes; a new fluorescent reporter for monitoring b-lactamase expression; a new fluorescent reporter for monitoring membrane potential; and, some wild speculation about the future.
Document emailed within 1 workday
Related Documents
Darvas, F. 2000: Retrometabolism design concepts and realization for combinatorial libraries Die Pharmazie 55(3): 243del Río, G.; Osuna, J.; Soberón, X. 1994: Combinatorial libraries of proteins: analysis of efficiency of mutagenesis techniques Biotechniques 17(6): 1132-1139
Eichler, J.; Lucka, A.W.; Houghten, R.A. 1994: Cyclic peptide template combinatorial libraries: synthesis and identification of chymotrypsin inhibitors Peptide Research 7(6): 300-307
Jacoby, E.; Davies, J.; Blommers, M.J.J. 2003: Design of small molecule libraries for NMR screening and other applications in drug discovery Current Topics in Medicinal Chemistry 3(1): 11-23
Blondelle, S.E.; Crooks, E.; Ostresh, J.M.; Houghten, R.A. 1999: Mixture-based heterocyclic combinatorial positional scanning libraries: discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans Antimicrobial Agents and ChemoTherapy 43(1): 106-114
Fernández-Metzler, C.L.; Owens, K.G.; Baillie, T.A.; King, R.C. 1999: Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates Drug Metabolism and Disposition: the Biological Fate of Chemicals 27(1): 32-40
Solov'ev, I.V.; Iurov, I.B.; Vorsanova, S.G.; Marcais, B.; Rogaev, E.I.; Kapanadze, B.I.; Brodianskiĭ, V.M.; Iankovskiĭ, N.K.; Roizes, G. 1998: Study of alpha-satellite DNA in cosmid libraries, specific for chromosomes 13, 21, and 22, using fluorescence in situ hybridization Genetika 34(11): 1470-1479
Eliseev, A.V. 1998: Emerging approaches to target-assisted screening of combinatorial mixtures Current Opinion in Drug Discovery and Development 1(1): 106-115
Guo, Z.-r. 2008: Strategy of molecular drug design: hits, leads and drug candidates Yao Xue Xue Bao 43(9): 898-904
Kubinyi, H. 1998: Combinatorial and computational approaches in structure-based drug design Current Opinion in Drug Discovery and Development 1(1): 16-27
Beeley, N.; Berger, A. 2000: A revolution in drug discovery. Combinatorial chemistry still needs logic to drive science forward Bmj 321(7261): 581-582
Kassarjian, A.; Schellenberger, V.; Turck, C.W. 1993: Screening of synthetic peptide libraries with radiolabeled acceptor molecules Peptide Research 6(3): 129-133
Kiselyov, A.S. 2006: The concept of Focused Diversity: a new algorithm for building screening libraries Idrugs: the Investigational Drugs Journal 9(3): 193-198
Jimonet, P.; Jäger, R. 2004: Strategies for designing GPCR-focused libraries and screening sets Current Opinion in Drug Discovery and Development 7(3): 325-333
Borromei, A. 1977: EEG screening of candidates for underwater activity Minerva Medica 68(20): 1323-1356
Harline, M.C.; Kandala, J.C.; Sage, R.D.; Guntaka, R.V.; DeAngelo, A. 1992: Improved method for screening cDNA expression libraries for DNA-binding proteins Biotechniques 13(3): 388-391
Wood, P.L. 1998: Peptoid drug discovery: the choice of scaffolds for combinatorial chemistry/HTS and subsequent substitutions for parallel synthesis/lead optimization Current Opinion in Drug Discovery and Development 1(1): 34-40
Singer, L.G.; Weinacker, A.B.; Levin, L.; Doyle, R.L.; Theodore, J. 2001: Diagnostic yield of screening colonoscopies in lung transplant candidates Transplantation 72(3): 530-532
Cox, R.H. 1988: Utilization of psychomotor screening for USAF pilot candidates: enhancing predictive validity Aviation Space and Environmental Medicine 59(7): 640-645
Krotovskaia, A.R.; Koloteva, M.I.; Luk'ianiuk, V.I.; Vil'-Vil'iams, I.F.; Bazhanova, T.M. 2006: On medical screening of civilian candidates for cosmonauts by exposure to the head-to-pelvis acceleration profiles Aviakosmicheskaia i Ekologicheskaia Meditsina 40(2): 9-13