Lipids in the cell nucleus
Bucki, R.; Górski, J.
Postepy Higieny i Medycyny Doswiadczalnej 51(3): 319-328
1997
ISSN/ISBN: 0032-5449 PMID: 9333783 Document Number: 482769
The paper contains available data on the content, composition and metabolism of different lipid fractions in the nuclei. The results on physiological function of the nuclear lipids are also included. Nuclear phosphatidylinositols have been shown to play a role of messengers signalling from the cytoplasm to the nuclei. Most sphingomyelin is located in the nucleoplasm and it effects stability of DNA. A role of nuclear triacylglycerols remains unknown. Polyunsaturated long chain fatty acids control transcription of genes encoding lipogenic and glycolytic enzymes. Cholesterol present in the nuclear envelope plays only structural function, but that present in chromatin may be involved in regulation of cholesterol biosynthesis.