Treatment of general toxic lesions caused by sulfur and nitrogen mustard in rats
Milosavljević, Z.
Godisnjak Vojnomedicinske Akademije 27: 79-82
1985
ISSN/ISBN: 0352-664X PMID: 3870999 Document Number: 4813
Based on the recent pathognomic accomplishment in the mechanisms of toxic actions, the favorable degree of protection was achieved by several drugs in acute poisoning of rats with sulfur and nitrogen mustards. It has been established that dexamethasone, promethazine, vitamin E, heparin and sodium thiosultate (a) prolonged the survival time in animals poisoned by 3 LD-50-s of toxic agents, (b) diminished the lethality (with the protective indices ranging from 1.5 to 2,7), (c) antagonized the decrease of body weigght, and (d) lessened the degree of pathological organ changes. The simultaneous administration of two or three of the drugs mentioned, cf which sodium thiosulfate as chemical inactivator of the toxic agents was basic and consonant component, led to the further increase in effectiveness. It is concluded that satisfactory results obtained in this study speak in favor of the basic pathological effects of mustard gases, as well as possible causes and their possible ways of action.
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