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New intron-containing human tRNA (Leu) genes

Karwowska, U.; Szweykowska-Kulińska, Z.

Acta Biochimica Polonica 44(4): 791-794

1997

ISSN/ISBN: 0001-527X
PMID: 9584861
Document Number: 480551
Three new human nuclear tRNA(Leu) genes have been isolated and sequenced using the PCR technique. Two of them represent genes containing a CAA anticodon and both contain introns of 22 nucleotides in length but differing in sequence. Intron-containing prolongated anticodon stems can be folded into a secondary structure similar to that of yeast pre-tRNA(Leu). The evolutionary conserved secondary structure suggests the same role of intron sequences in the human and yeast pre-tRNA(Leu) maturation pathway.

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