Effect of nipradilol on aqueous flow in glaucoma patients treated with timolol
Nagataki, S.; Koseki, Y.; Yamakawa, R.; Koibuchi, H.
Nippon Ganka Gakkai Zasshi 101(3): 252-256
1997
ISSN/ISBN: 0029-0203 PMID: 9086746 Document Number: 476690
The effect of nipradilol solution (KT-210) on aqueous flow was evaluated using fluorophotometry in 10 patients (6 primary open-angle glaucoma and 4 ocular hypertension) treated with timolol for more than one month. A single dose of 0.5% timolol was instilled into both eyes at 8 AM, and 0.25% KT-210 or placebo was instilled into both right and left eye at 11 AM ; the treated eye was chosen randomly. Aqueous flow was measured every hour from 9 AM to 3 PM. There was no significant difference in pretreatment aqueous flow between the two eyes; 1.98 +- 0.53 mu-l/min in the KT-210 treated eyes, and 1.98 +- 0.76 mu-l/min in the placebo treated eyes. The flow measured 1 to 4 hours after KT-210 instillation was 1.66 +- 0.69 mu-l/min, 2.23 +- 1.02 mu-l/min, 2.20 +- 0.67 mu-l/min, and 1.68+-0.64 mu-l/min, respectively. This flow did not differ significantly from the flow in the placebo treated eyes (1.83 +- 0.86 mu-l/min, 1.79 +- 0.69 mu-l/min, 2.26 +- 0.58 mu-l/min, and 1.84 +- 0.32 mu-l/min).