Short and long-term hypotensive effect of timolol-gel and latanoprost instillation in normal-tension glaucoma
Hashimoto, T.; Hara, T.; Takahashi, Y.; Kubota, S.; Kubota, M.; Tsuru, T.
Nippon Ganka Gakkai Zasshi 108(8): 477-481
2004
ISSN/ISBN: 0029-0203 PMID: 15457989 Document Number: 583957
Purpose : To confirm the predictive value of the results of a 4-week trial of latanoprost alone, timolol-gel alone, or a combination of the two in normal-tension glaucoma (NTG) patients, when compared with the hypotensive response after a 6-month trial using the same combination of eye drops for the same patients. Methods : One eye each of 45 NTG patients was used in a prospective 4-week trial of latanoprost alone, timolol-gel alone, or a combination of the two. Patients continued using the eye drops for 6 months, according to the results of the trial. The correlation of the results of the 6-moth use and the baseline data, and the baseline data and the results of the 4-week trial were evaluated by the paired-t test. Results : The intraocular pressure (IOP) s of patients using timolol-gel alone were 13.9 mmHg at the base line, 9.7 mmHg after the trial, and 12.0 mmHg after 6-month use (baseline, trial : p0.05). IOPs when using latanoprost alone were 15.3 mmHg at baseline, 11.7 mmHg after the trial, and 11.5 mmHg after 6-month use (baseline : p0.05, trial : p=0.33). IOPs using timolol-gel and latanoprost in combination were 14.8 mmHg at baseline, 11.4 mmHg after the trial, and 12.0 mmHg after 6-month use (baseline : p0.05, trial : p=0.14). Conclusion : The result of the 4-weeks trial of latanoprost alone or in combination with timololgel can be indicative of the IOP after 6-month use.