Ocular hypotensive effect of pilocarpine in latanoprost treated eyes; a pilot study
Teus Guezala MA; Arranz Márquez E; Morales Bertrand J; Marcos De La Huerga A
Archivos de la Sociedad Espanola de Oftalmologia 75(11): 735-740
2000
ISSN/ISBN: 0365-6691 PMID: 11151262 Document Number: 519297
To study the ocular hypotensive effect of pilocarpine in latanoprost treated eyes. We measured the IOP in both eyes of 25 patients, before and after instillation of pilocarpine 2% in one eye, and placebo in the other. This is a prospective, double blind, placebo-controlled study. We found that the mean change in IOP of the study eyes was +0.4 on average (range of change from -3 to +5 mmHg), compared with the control, placebo treated eyes (p=0.5). The acute administration of pilocarpine in Latanoprost treated eyes seems to have a paradoxical effect on IOP, as the IOP may increase or decrease.