The metabolism and bactericidal properties of the blood neutrophilic granulocytes in experimental typhoid intoxication
Ovcharenko, N.I.; Borisova, M.A.; Shpak, S.I.; Danilesku, A.E.; Krivosheev, V.N.
Mikrobiolohichnyi Zhurnal 59(2): 78-84
1997
ISSN/ISBN: 0201-8462 PMID: 9221062 Document Number: 475965
The levels of succinate dehydrogenase (SDG), lactate dehydrogenase (LDG), glucose-6-phosphate-dehydrogenase (G-6-PDG), myeloperoxydase (MPO), glycogen and cationic proteins were determined in the neutrophilic granulocytes of peripheral blood of 79 rabbits after experimental contamination by endotoxin of S. typhi. The bactericidal system of neutrophils was stimulated due to the depression of SDG, activation of LDG and G-6-PDG levels. Administration of indometacinum and chlotasolum blockaded the cyclooxygenase fermentative system of prostaglandin synthesis and thus decreased the activity of S. typhi endotoxin.