UFT plus leucovorin in advanced hepatobiliary tumors and pancreatic adenocarcinomas
Mani, S.
Oncology 11(9 Suppl 10: 124-127
1997
ISSN/ISBN: 0890-9091 PMID: 9348584 Document Number: 474848
UFT (tegafur and uracil) has been studied extensively in Japan, with documented efficacy in hepatobiliary and pancreatic cancer. In the United States, UFT with or without leucovorin has not undergone phase II testing in these malignancies. Our current trial is designed primarily to assess the efficacy in terms of response rates to UFT with leucovorin in patients with advanced hepatobiliary and pancreatic cancer. Secondary objectives include determining response duration, time to disease progression, overall survival, quality of life, and toxicity.