UFT/leucovorin in advanced squamous cell carcinoma of the head and neck administered with radiotherapy

Mercke, C.

Oncology 14(10 Suppl 9: 79-81

2000


ISSN/ISBN: 0890-9091
PMID: 11098501
Document Number: 524297
This is an open-label, nonrandomized phase I study to determine the maximum tolerated dose and dose-limiting toxicity of UFT plus leucovorin when given concomitantly with hyperfractionated radiotherapy in patients with head and neck cancer. The study period is determined by the course of radiotherapy, which is given as 1.7 Gy per fraction twice daily for 5 days (Monday to Friday) in 2 consecutive weeks, followed by 1 week of rest, and subsequently another 2 weeks of radiotherapy (Monday to Friday plus Monday to Thursday). Total duration of therapy will be 5 weeks.

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