A case of advanced rectal cancer treated with leucovorin, fluorouracil, and oxaliplatin plus panitumumab preoperative chemotherapy
Takahashi, H.; Ishikawa, T.; Iwata, N.; Baba, H.; Masuda, T.; Okazaki, S.; Matsuyama, T.; Ishiguro, M.; Kobayashi, H.; Iida, S.; Uetake, H.; Sugihara, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 40(12): 1953-1955
2013
ISSN/ISBN: 0385-0684 PMID: 24393977 Document Number: 667892
A 58-year-old woman had a very large advanced rectal cancer( with wild-type K-RAS expression). Abdominal computed tomography( CT) revealed a space-occupying lesion in the pelvis and an enlarged lymph node. We established a diagnosis of unresectable rectal cancer and subsequently performed transverse colostomy. The patient received 6 courses of Leucovorin, fluorouracil, and oxaliplatin( mFOLFOX6) plus panitumumab( Pmab), 2 courses of simplified Leucovorin plus 5-fluorouraci(l sLV5-FU) plus Pmab, and 1 course of Pmab. The size of the primary tumor decreased remarkably after chemotherapy. Low anterior resection was performed. The pathological stage was T4a, N0, M1, Stage IVa. The results from this case suggest that mFOLFOX6 plus Pmab preoperative chemotherapy is a useful regimen for the treatment of locally advanced K-RAS wild-type rectal cancer.