A comparative study on the effect of felodipine and propranolol on serum lipid profile of rabbits
Swain, T.R.; Das, M.; Kanungo, S.; Mukherji, D.; Mishra, S.S.; Das, M.C.
Indian Journal of Physiology and Pharmacology 41(3): 269-274
1997
ISSN/ISBN: 0019-5499 PMID: 10232772 Document Number: 474457
Effect of felodipine on serum lipids of rabbits was studied and was compared with that of propranolol. Lipid parameters were estimated at basal (0 wk), end of 4th and 16th week of diet/drug administration by using standard kits for analysis. There was a significant increase in mean serum cholesterol, TG, VLDL-C, LDL-C and decrease in HDL-C, (P lt 0.05) in the group of rabbits receiving Atherogenic diet (AD)/Propranolol. This effect was maximally observed in rabbits receiving both AD and propranolol. This change was satisfactorily prevented when felodipine was administered from very beginning (P lt 0.001). In addition, there was a significant increase in HDL-c (28.89%) of rabbits receiving felodipine from beginning. Thus both AD and propranolol have dyslipidemic effect and early administration of felodipine favorably changes all lipid parameters.