The neurovirulence of flaviviruses in crab-eating monkeys (Macaca fascicularis)
Angsubhakorn, S.; Moe, J.B.; Latendresse, J.R.; Ward, G.S.; Ngamprochana, M.; Sahaphong, S.; Bhamarapravati, N.
Southeast Asian Journal of Tropical Medicine and Public Health 17(4): 604-612
1986
ISSN/ISBN: 0125-1562 PMID: 3033834 Document Number: 4735
The neurovirulent properties of attenuated dengue-2 and yellow fever (YF) vaccines, dengue-2 (DEN-2) and Japanese encephalitis (JE) viruses were studied in crab-eating monkeys (Macaca fascicularis). Number of central nervous system sites (as proportion affected) with neurovirulence (NV) lesions were compared. The results indicate that these monkeys reliably developed NV-lesion when inoculated with either JE or YF vaccine viruses (87%). NV-lesions occurred in a minority when inoculated with DEN-2 vaccine virus, were of minimal severity (9%), were probably biologically insignificant, and were of equal or less severity than lesions produced by its parental virus (10%).
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