Neurovirulence effects of dengue-2 viruses on the rhesus (Macaca mulatta) brain and spinal cord
Angsubhakorn, S.; Moe, J.B.; Marchette, N.J.; Palumbo, N.E.; Yoksan, S.; Bhamarapravati, N.
Southeast Asian Journal of Tropical Medicine and Public Health 18(1): 52-55
1987
ISSN/ISBN: 0125-1562 PMID: 3660068 Document Number: 4372
Vaccines prepared from attenuated virus can cause symptomatic viral infection of the central nervous system. In the present study, dengue-2 parental and its live attenuated viruses were tested by intrathalamic and intraspinal injections in rhesus monkeys. The dengue-2 viruses were found to be only very weakly neurovirulent when injected directly into the brain or spinal cord of rhesus monkeys.
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