The course of untreated Plasmodium inui infections in the rhesus monkey (Macaca mulatta)
Schmidt, L.H.; Fradkin, R.; Harrison, J.; Rossan, R.N.; Squires, W.
American Journal of Tropical Medicine and Hygiene 29(2): 158-169
1980
ISSN/ISBN: 0002-9637 PMID: 6768313 Document Number: 168232
Thirty-one Macaca mulatta were infected with Plasmodium inui, 27 by inoculation with trophozoites and 4 with sporozoites. Infections in 9 were followed to self-cure. In 22 monkeys the infections were interrupted (in 17 by chemotherapy 454 to 3931 days after onset of patency and in 5 by death 491 to 1025 days after onset of patency). Substantial monkey-to-monkey variations were encountered in the intensity of the parasitaemia and its cyclic undulations, in the morbid features of the disease, and in the duration of infection. In most monkeys there was no evidence of morbidity attributable to malarial infection; in 2, reactions were severe enough to lead to death. With due allowance for premature interruptions, the majority of infections could be expected to persist for 4 to 6 years.