Neonatal low-level lead exposure in monkeys (Macaca fascicularis) : effect on two-choice non-spatial form discrimination
Rice, D.C.; Willes, R.F.
Journal of Environmental Pathology and Toxicology 2(4): 1195-1203
1979
ISSN/ISBN: 0146-4779 PMID: 109561 Document Number: 142543
Monkeys were dosed orally with 500 microgram/kg/day of lead as lead acetate from day 1 of life. No overt signs of lead toxicity were observed. At 2--3 years of age they were tested on a two-choice non-spatial form discrimination using a WGTA apparatus. Treated monkeys showed deficits compared to controls on a series of 20 discrimination reversals; there was no difference between the groups in the effect of a series of "overtraining" trials introduced between reversals.