Dauricine inhibited L-type calcium current in single cardiomyocyte of guinea pig
Guo, D.L.; Zhou, Z.N.; Zeng, F.D.; Hu, C.J.
Zhongguo Yao Li Xue Bao 18(5): 419-421
1997
ISSN/ISBN: 0253-9756 PMID: 10322931 Document Number: 472777
To study the effect of dauricine (Dau) on L-type calcium current in guinea pig ventricular myocytes. Using whole-cell recording method to record L-type calcium current (ICa) in single ventricular cell of guinea pig. Dau 1, 10, and 100 mumol.L-1 markedly reduced ICa by 15.2% +/- 2.2%, 41% +/- 5%, and 82% +/- 8%, respectively. After washing out, ICa partially recovered. Dau inhibited ICa at 3 Hz and 1 Hz to a similar extent, its effect on ICa appeared to be not frequency-dependent. Dau had a calcium channel blocking effect.