Effects of 3,6-dimethylamino-dibenzopyriodonium formiate on action potential and slow inward calcium current in isolated guinea pig ventricular myocytes
Cui, Y.; Tan, Y.H.
Yao Xue Xue Bao 28(7): 504-506
1993
ISSN/ISBN: 0513-4870 PMID: 8285050 Document Number: 417719
The effects of 3,6-dimethylamino-dibenzopyriodonium formiate (IHC-64) on action potential and slow inward calcium current (I-si) were investigated in isolated guinea pig ventricular myocytes using whole cell voltage clamp recording. IHC-64 (20 and 200 mu-mol/L) was shown to markedly decrease APD-20 and APD-90. However, in the presence of nisoldipine, no obvious effects of IHC-64 on APD-20 could be detected. Under voltage clamp conditions, IHC-64(20 and 200 mu-mol/L) caused a significant decrease in I-si. The results indicate that IHC-64 can block the calcium channels in isolated guinea pig ventricular myocytes.