Protective effects of 3,6-dimethylamino-dibenzopyriodonium edetate on global ischemia reperfused isolated rat hearts
Ji, G.J.; Zhang, J.Z.; Liu, D.Q.; Zhao, D.H.; Sheng, B.H.
Zhongguo Yao Li Xue Bao 14(3): 206-210
1993
ISSN/ISBN: 0253-9756 PMID: 8237392 Document Number: 405665
The effects of 3,6-dimethylamino-dibenzopyriodonium edetate (IHC-72) on global ischemia reperfused rat hearts were investigated. In the isolated working rat heart, 40-min global ischemia followed by 30-min reperfusion resulted in increases of ventricular tachycardia (VT) and ventricular fibrillation (VF), increases of creatine kinase (CK) release and malondialdehyde (MDA) contents, but decreased superoxide dismutase (SOD) activity. Following ischemia and reperfusion, the accumulation of myocardial calcium increased. IHC-72 50 mu-mol cntdot L-1 given 10 min before ischemia and during reperfusion decreased the cardiac CK release, VT, and VF, reduced the MDA contents, prevented the reduction of SOD activity and attenuated the accumulation of myocardial calcium and sodium vs control. The results indicated that IHC-72 protected myocardial reperfused injury.